Welcome to the ADMIRE documentation

ADMIRE is a semi-automatic analysis pipeline and visualization tool for Infinium HumanMethylation450K and Infinium MethylationEpic assays.

Use ADMIRE online: bioinformatics.mpi-bn.mpg.de

Overview and Objective

DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and the stage of a disease. Besides whole genome bisulfit sequencing, Illumina HumanMethylation450K Assays represent a versatile and cost-effective tool to investigate changes of methylation patterns at CpG sites. ADMIRE was developed as an open source, semi-automatic analysis pipeline and visualization tool for Illumina HumanMethylation450K Assays.

Features

• Automatic filtering and normalization
• Statistical testing and multiple testing correction
• Supports arbitrary number of samples and sample groups
• Differential methylation analysis on pre-calculated and individual genomic regions
• Provides ready-to-plug-in files for genome browsers (like IGV)
• Provides publication-ready figures for the most differentially methylated regions
• Performs gene set enrichment analysis on predefined and individual gene sets

How to cite?

Please cite the paper describing ADMIRE when using the web service or command line version in your research:

Preussner J, Bayer J, Kuenne C and Looso M. ADMIRE: Analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay. Epigenetics & Chromatin (2015).

Contribute

• Issue Tracker: https://github.molgen.mpg.de/loosolab/admire/issues
• Source Code: https://github.molgen.mpg.de/loosolab/admire

Support

If you are having issues, please feel free to send an e-mail to Jens Preußner (jens.preussner@mpi-bn.mpg.de).

License

The project is licensed under the MIT license.